TABLE 3
Noncompartmental data for M and MG for intravenous and intraduodenal data of morphine sulfate administration to the rat (305 ± 16 g)
Values are presented as means ± S.D.
| Parameter | Intravenous Dosing (n = 4) | Intraduodenal Dosing (n = 3) | Ratio of Intraduodenal/ Intravenous Dosing | P Value |
|---|---|---|---|---|
| M | ||||
| Dose (μmol·kg−1)a | 14.9 ± 1.6 | 26.6 ± 0.40 | 1.79 | 0.0001* |
| Rat (g) | 299 ± 6 | 307 ± 12 | 1.03 | 0.576 |
 (nM·min·nmol dose−1) | 183 ± 98 | 39.9 ± 6.0 | 0.218 | 0.057 |
 (nM·min·nmol dose−1) | 188 ± 97 | 43.2 ± 6.1 | 0.229c | 0.053 |
 (min) | 61 ± 12 | 67 ± 23 | 1.09 | 0.691 |
| CLtot (ml·min−1) | 6.57 ± 3.28 | |||
 (% dose M excreted into bile at 4h) | 0.984 ± 0.508 | 0.559 ± 0.095 | 0.568 | 0.221 |
 as (% dose M excreted into urine at 4h) | 33.4 ± 15.1 | 7.16 ± 2.68 | 0.215d | 0.034* |
| Percent dose as M excreted into urine and bile (4h) | 34.3 ± 15.4 | 7.71 ± 2.60 | 0.225 | 0.034* |
CLR or  (ml·min−1) | 2.21 ± 1.24 | 1.77 ± 0.45 | 0.800 | 0.589 |
| MG | ||||
 (nM·min·nmol dose−1) | 26.2 ± 6.8 | 53 ± 28 | 2.02 | 0.114 |
 (nM·min·nmol dose−1) | 30.3 ± 8.2 | 60.5 ± 29.0 | 2.0 | 0.10 |
 (min) | 79 ± 11 | 72 ± 5 | 0.911 | 0.82 |
 (% dose of MG excreted into bile at 4h) | 32.8 ± 11.3 | 58.8 ± 6.1 | 1.79 | 0.016* |
 (% dose MG excreted into urine at 4h) | 6.6 ± 3.1 | 30.7 ± 13.1 | 4.65 | 0.015* |
 or  / (ml·min−1) | 2.63 ± 1.19 | 6.40 ± 3.29 | 2.43 | 0.08 |
| Percent dose as MG into urine and bile (4h) | 39.5 ± 12.7 | 89.5 ± 7.0 | 2.26 | 0.002* |
 | 0.212 ± 0.078 | 0.541 ± 0.274 | 2.55 | 0.066 |
| Percent dose – total recovery in bile and urine (4h)b | 73.8 ± 11 | 97.2 ± 8.8 | 1.32 | 0.030* |