| Ratio of effective uptake/efflux clearance of M in intestine, or intestine to blood partitioning of unbound morphine | 0.137 | 0.531 |
| Ratio of effective uptake/efflux clearance of M in liver, or liver to blood partitioning ratio of unbound morphine | 1.42 | 2.46 |
FI | Intestinal availability of M | 0.654 | 0.457 |
| | | |
| d | 0.629 | 0.282 |
FL | Hepatic availability of M | 0.574 | 0.574 |
| | | |
| d | 0.710 | 0.717 |
Fsys = Fabs * FI * FL | Systemic bioavailability: | 0.334 | 0.242 |
| | | |
| | 0.402 | 0.186 |
| Intestinal availability of MG | 0.95 | 0.89 |
| | | |
| Hepatic availability of MG | 0.12 | 0.22 |
| | | |
| Fraction of hepatic clearance of M forming MG | 0.948 | 0.854 |
| | | |
a | Fraction of total body clearance of M forming MG (note that fe = 0.334 from Table 3) | 0.631 | 0.569 |
b | Fractional contribution of intestine to intestinal-liver removal | 0.460 | 0.093 |
| | 0.570e | 0.171e |
c | Fractional contribution of liver to intestinal-liver removal | 0.540 | 0.907 |
| | 0.430e | 0.829e |