Serum biochemistry parameters in the bile-duct-cannulated rats
Data represent the mean ± S.E.M.
| Parameter | Normal BDC Rats (TBIL < 0.2) | BDC Rats with Hyperbilirubinemia | ||
|---|---|---|---|---|
| Mild (TBIL = 0.2–0.79) | Moderate (TBIL = 0.8–1.99) | Severe (TBIL ≥ 2.0) | ||
| n | 79 | 11 | 3 | 1 |
| TBIL (mg/dl) | 0.05 ± 0.01 | 0.39 ± 0.03** | 1.19 ± 0.18** | 4.96 |
| DBIL (mg/dl) | 0.04 ± 0.005 | 0.35 ± 0.03** | 1.11 ± 0.17** | 4.39 |
| IDBIL (mg/dl) | 0.005 ± 0.001 | 0.05 ± 0.01** | 0.08 ± 0.02** | 0.57 |
| AST (IU/l) | 207 ± 12 | 236 ± 27 | 430 ± 50** | 549 |
| ALT (IU/l) | 62 ± 3 | 78 ± 11 | 135 ± 24** | 211 |
| LAP (IU/l) | 85.2 ± 1.4 | 86.5 ± 4.4 | 97.4 ± 6.6 | 95.6 |
| ALP (IU/l) | 1196 ± 35 | 1850 ± 176** | 1460 ± 308 | 1697 |
| GGT (IU/l) | 2.39 ± 0.23 | 6.06 ± 0.89** | 22.13 ± 11.01** | 50.79 |
ALP, alkaline phosphatase; ALT, alanine aminotransferase; AST, aspartate aminotransferase; LAP, leucine aminopeptidase.
↵** P < 0.01 versus normal BDC rats.