TABLE 1

Tissue-to-blood ratios of radioactivity in selected tissues after oral administration of [14C]-osimertinib (4 mg/kg) to male partially pigmented rats and male and female albino rats

Male Partially Pigmented RatsMale Albino RatsFemale Albino Rats
0.5 h1 h6 h24 h2 days7 days21 days60 days1 h6 h24 h1 h6 h24 h
Bile ducts63.456.528.72.631.570.39NCNC66.827.42.9929.119.03.25
Blood1.001.001.001.001.001.001.00NC1.001.001.001.001.001.00
Brain1.062.171.850.370.190.220.23NC1.411.800.242.092.250.49
Liver32.624.513.33.232.181.010.41NC29.617.34.4735.818.64.60
Lung14.021.320.43.111.240.850.81NC25.233.93.2137.343.16.10
Muscle0.901.682.010.460.380.410.27NC1.952.330.412.512.150.55
OvaryNDNDNDNDNDNDNDNDNDNDND5.3814.61.94
Pituitary11.610.523.85.352.311.221.05NC14.932.914.312.031.913.6
Renal cortex11.715.722.211.48.404.071.06NC18.526.413.918.315.24.69
Renal medulla3.829.3011.52.891.891.120.60NC10.614.52.8717.520.003.00
Skin (non-pigmented)0.6401.402.180.5780.3100.1990.147NCNDNDNDNDNDND
Skin (pigmented)1.012.102.873.152.025.340.170NCNDNDNDNDNDND
SkinNDNDNDNDNDNDNDND1.302.220.490.771.821.18
Spleen11.119.422.75.383.092.773.40NC23.826.64.0729.232.710.8
Testis0.440.772.471.080.770.760.68NC0.581.710.70
Thyroid13.912.110.82.631.711.841.27NC18.720.12.9420.315.13.16
Uvea and RPE7.6215.071.997.2173151180NC3.343.721.062.941.390.79
  • NC, not calculable; ND, not done; RPE, retinal pigment epithelium; —, not applicable.