TABLE 1

Mean ± S.D. pharmacokinetic parameters of total radioactivity and ombitasvir

AnalyteCmaxTmaxAUC0-lastAUC0-∞t1/2
ng equivalent/g or ng/mlhng equivalent⋅h/g or ng⋅h/mlng equivalent⋅h/g or ng⋅h/mlh
Total radioactivity142.5 ± 14.324 ± 017,411 ± 170430,470 ± 6568
Ombitasvir27.8 ± 6.084.0 ± 0359 ± 63.9366 ± 63.130.3 ± 9.80

  • AUC0-last, area under curve from 0 hr to the last sampling time points; AUC0-∞, area under the concentration-time curve from time zero to infinity.