Parameter | Normal Group | Mild HB Group |
---|---|---|
AUC (ng⋅h/ml) | 1180 ± 159 | 2380 ± 505 |
CLtotal (ml/h/kg) | 4400 ± 699 | 2310 ± 521 |
Vd (ml/kg) | 840 ± 69 | 497 ± 77* |
CLbile (ml/h/kg) | 2390 ± 247 | 661 ± 367* |
CLnon-bile (ml/h/kg) | 2020 ± 505 | 1650 ± 241 |
Biliary excretion (% of dose) | 55.0 ± 4.8 | 25.5 ± 9.1* |
Cplasma,1.5h (ng/ml) | 12.9 ± 7.6 | 17.9 ± 9.5 |
Cliver,1.5h (ng/g) | <5 (3.39 ± 0.93)a | 14.3 ± 4.5 |
Cliver-to-Cplasma ratio | <0.80 ± 0.42 (0.40 ± 0.12)a | 1.2 ± 0.4 |
Biliary flow rate (ml/h/kg) | 5.78 ± 0.46 | 6.89 ± 0.74 |
TBIL (mg/dl) | 0.09 ± 0.06 | 0.55 ± 0.12* |
GGT (IU/l) | 2.20 ± 0.98 | 7.14 ± 1.35* |