TABLE 2

IC50 values for seven drugs versus six pooled recombinant P450 enzymes

CYP1A2CYP2C8CYP2C9CYP2C19CYP2D6CYP3A4
┬ÁM
Bupropion>50>50>504.847.11>50
Diltiazem>50>50>50>5021.211.6
Fluoxetine>50>50>500.4360.79315.8
Itraconazole>5014.9>506.0>500.319
Amiodarone>5045>5029.516.626.9
Citalopram>50>50>50>5028.6>50
Gemfibrozil>5027.222.78.66>50>50