Human plasma Cavg values of drugs and metabolites used in this study
| Drug (Dosage) | Drug/Metabolite | Cavga | Reference |
|---|---|---|---|
| µM | |||
| Bupropion (200 mg BID) | Bupropion | 0.16 | Golden et al. (1988) |
| 4-Hydroxybupropion | 5.7 | ||
| Erythro-dihydrobupropion | 0.44 | ||
| Threo-dihydrobupropion | 2.3 | ||
| Diltiazem (60 mg TID) | Diltiazem | 0.33 | Höglund and Nilsson (1989) |
| Desmethyldiltiazem | 0.17 | ||
| Desacetyldiltiazem | 0.078 | ||
| Fluoxetine (40 mg QD) | Fluoxetine | 0.76 | Harvey and Preskorn (2001) |
| Norfluoxetine | 0.86 | ||
| Itraconazole (200 mg BID) | Itraconazole | 2.7 | Barone et al. (1993) |
| Hydroxyitraconazole | 4.7 | ||
| Amiodarone (6.3 mg/kg per day) | Amiodarone | 3.5 | Stäubli et al. (1985) |
| N-Desethylamiodarone | 2.1 | ||
| Citalopram (40 mg QD) | Citalopram | 0.19 | Sindrup et al. (1993) |
| Desmethylcitalopram | 0.074 | ||
| Didesmethylcitalopram | 0.015 | ||
| Gemfibrozil (600 mg BID) | Gemfibrozil | 35 | Tornio et al. (2008) |
| Gemfibrozil glucuronide | 23 |
AUC, area under the curve; BID, twice daily; QD, once per day; TID, three times daily.
↵a Cavg was calculated as the AUC(0 − τ)/τ, where τ is the dosing interval.