TABLE 1

Pharmacokinetic parameters (mean ± S.D.) of paritaprevir, ritonavir and total radioactivity in plasma after a 200/100 mg oral dose of [¹⁴C]paritaprevir /ritonavir

Analyte	C_max	T_max	AUC_0–last	AUC_0-∞	t_1/2
	ng-eq/g or ng/ml	h	ng-eq/h/g or ng/h/ml	ng-eq/h/g or ng/h/ml	h
Total radioactivity	1155 ± 798^*	3.5 ± 1.9	4960 ± 3600^*	6952 ± 2297^*
Paritaprevir	886 ± 774	3.0 ± 1.2	4610 ± 3440	4630 ± 3430	5.27 ± 1.08
Ritonavir	998 ± 569	4.5 ± 1.9	5460 ± 1960	5580 ± 1910	4.01 ± 0.73

AUC_0–∞, AUC from time 0 to infinity.
↵* Total radioactivity Cmax unit, ng-eq/g; AUC unit, ng-eq/h/g.