TABLE 3

Percentages of excretory metabolites of in humans after administration of a single 200/100 mg oral dose of [14C]paritaprevir /ritonavir (n = 4)

MetaboliteFeces
(0–192 h)Urine
(0–168 h)Total
Total radioactivity87.88.76
Paritaprevir1.10.051.15
M28.550.138.68
M60.78ND0.78
M3/M18*7.47ND7.47
M131.678.5710.2
M141.12ND1.12
M171.08ND1.08
M22/M23**2.78ND2.78
M243.32ND3.32
M2959.90.0159.9

  • ND, not detected.

  • ↵* M3 and M18 were coeluting metabolites in fecal sample analysis.

  • ↵** M22 and M23 were coeluting metabolites in fecal sample analysis.