Percentage of metabolisma of osimertinib, AZ5104, and AZ7750 through recombinant expressed cytochrome isoforms
| Cytochrome Isoform | Compound | ||
|---|---|---|---|
| Osimertinib | AZ5104 | AZ7750 | |
| 1A2 | 12.0 | 0.373 | ND |
| 2A6 | 15.5 | ND | ND |
| 2B6 | ND | ND | ND |
| 2C8 | ND | 3.19 | 0.129 |
| 2C9 | 15.5 | 0.160 | ND |
| 2C19 | ND | 0.958 | ND |
| 2D6 | ND | 0.285 | ND |
| 2E1 | 3.0 | ND | ND |
| 3A4 | 44.4 | 67.0 | 99.9 |
| 3A5 | 9.6 | 28.1 | ND |
↵a Relative contribution for the 10 displayed cytochrome isoforms only.
ND, not detected.