TABLE 2

Mean (n = 3) osimertinib remaining after incubation at 37°C for 6 hours in mouse, rat, dog, and human plasma, human serum albumin (HSA), solution and human α1-acid glycoprotein solution (AGP)

Osimertinib Concentration (μM)Osimertinib Remaining after 6 h (%)
MouseRatDogHumanHSAAGP
0.1153690<111101
1254388<0.111108
10433483<0.19.7105
1003032980.0914104