TABLE 3

Summary of clinical parameters applied to drug-drug interaction predictions

	Dose	MW	C_sys	f_u	C_{sys, free}	Reference
	mg		ng/ml		ng/ml
Clarithromycin	500	748.0	673	0.3	202	Gorski et al., 1998
Erythromycin	200	733.9	182.3	0.25	45.6	Okudaira et al., 2007
Mibefradil	100	495.6	520	0.005	2.6	Veronese et al., 2003
Troleandomycin	500	814.0	2000	0.15	300	Kharasch et al., 2004
Verapamil	80	454.6	157	0.1	15.7	Backman et al., 1994
VX-509	200	392.4	2508	0.1	251	Huang et al., 2014
Metabolite (M3)	—	408.4	275	0.3	82.5	Huang et al., 2014