Exposure of M1 formed from human or rat hepatic S9 incubations of 1 in the presence or absence of NADPH
| In Vitro Incubation | + NADPH | - NADPH |
|---|---|---|
| Human S9 | 7.7 ± 0.66 | 12.2 ± 0.68 |
| Rat S9 | 10.4 ± 0.90 | 15.7 ± 0.68 |
AUC expressed as the peak area ratio analyte/IS*min and represent means of triplicate determinations (± S.D.).