Parameters | Canagliflozin | Glibenclamide | Rosiglitazone | Metformin | Troglitazone | |||||
---|---|---|---|---|---|---|---|---|---|---|
SD | ZDF | SD | ZDF | SD | ZDF | SD | ZDF | SD | ZDF | |
AUC (μM*h) | 5.4 ± 0.6 | 8.6 ± 1.6a | 5.1 ± 1.5 | 10 ± 1.5b | 40 ± 12 | 32 ± 7 | 1.9 ± 0.4 | 1.5 ± 0.2 | 0.6 ± 0.1 | 1.1 ± 0.4a |
AUCinf (μM*h) | 5.8 ± 0.7 | 9.7 ± 1.8a | 5.3 ± 1.6 | 24 ± 6.3b | 40 ± 12 | 32 ± 7 | 1.9 ± 0.4 | 1.5 ± 0.2 | 0.6 ± 0.1 | 1.3 ± 0.6a |
CL (ml/min per kg) | 6.5 ± 0.8 | 4.0 ± 0.8b | 6.8 ± 1.6 | 1.5 ± 0.5b | 1.2 ± 0.3 | 1.5 ± 0.3 | 71 ± 16 | 90 ± 14 | 63 ± 10 | 35 ± 15a |
Vdss (l/kg) | 3.4 ± 0.3 | 2.4 ± 0.3b | 2.4 ± 0.2 | 3.6 ± 0.5b | 0.3 ± 0.0 | 0.2 ± 0.0 | 3.4 ± 2.3 | 3.7 ± 0.7 | 1.6 ± 0.6 | 4.7 ± 3.2 |
t1/2 (h) | 6.2 ± 0.6 | 7.6 ± 0.5b | 4.8 ± 0.8 | 31 ± 9b | 2.9 ± 0.2 | 2.7 ± 0.1 | 2.6 ± 3.6 | 1.1 ± 0.4 | 2.0 ± 1.2 | 5.6 ± 4.2 |