Compound and Matrix | Parent | Metabolism on the Bicyclo[1.1.1]Pentane Moiety | Metabolism on Other Moieties | |||
---|---|---|---|---|---|---|
Mono-Oxidation | P + 181 Da | Bis-Oxidation | Mono-/Bis-Oxidation + Dehydrogenation | Mono-Oxidation, etc. | ||
Compound 1 | ||||||
AIRLS9 (30 min) | 98 | 2 (1-1) | ND | ND | ND | ND |
HLS9 (30 min) | 99 | <1 (1-1, 1-2) | ND | ND | ND | ND |
RHep (2 h) | 99 | <1 (1-1) | ND | ND | ND | ND |
HHep (2 h) | 99 | <1 (1-1) | ND | ND | ND | ND |
BDC rat bile (0–24 h) | 1 | 27 (1-1), 1 (1-2) | 52 (1-3) | 3 (2 products) | 13 (4 products) | 4 |
BDC rat plasma (0.5, 1, 3, 6, 24 h) | 76‒95 | 4–16 (1-1), 2–11 (1-2) | ND | ND | ND | ND |
Compound 2 | ||||||
AIRLS9 (30 min) | 95 | 5 (2-1) | ND | ND | ND | ND |
HLS9 (30 min) | 99 | <1 (2-1) | ND | ND | ND | ND |
RHep (2 h) | 99 | <1 (2-1) | ND | ND | ND | ND |
HHep (2 h) | 99 | <1 (2-1) | ND | ND | ND | ND |
BDC rat bile (0–24 h) | 4 | 55 (2-1), 6 (2-2) | 6 (2-3) | 4 (1 product) | 18 (4 products) | 13 |
BDC rat plasma (0.5, 1, 3, 6, 24 h) | 100 | ND | ND | ND | ND | ND |
AIRLS9, Aroclor-induced rat liver S9; HHep, human hepatocyte; HLS9, human liver S9; ND, not detected; RHep, rat hepatocyte.