TABLE 4

Prediction of drug-drug interactions from in vitro parameters of time-dependent inhibition

Drug	k_inact	K_I	Predicted AUC_i/AUC^a	Clinical AUC_i/AUC
	min⁻¹	µM
Clarithromycin	0.07	5.2	12	7
Erythromycin	0.08	10.0	4	3
Mibefradil	0.21	0.2	16	9
Troleandomycin	0.04	0.1	24	15
Verapamil	0.02	1.6	4	4

AUC_i/AUC, fold-change in clinical exposure of midazolam when coadministered with an inhibitor (AUC_i), relative to the control state (AUC).
↵^a Predicted AUC ratios calculated using eq. 5.