Concentration | Rat | Human | ||||
---|---|---|---|---|---|---|
+NADPH + hydralazine | +NADPH | -NADPH | +NADPH +hydralazine | +NADPH | -NADPH | |
CLint | CLint | CLint | CLint | CLint | CLint | |
0.1 μM | 41.5 ± 4.6 | 99.6 ± 8.3 | 25.3 ± 2.6 | 39.3 ± 1.1 | 48.8 ± 7.6 | 7.2 ± 1.1 |
1 μM | 22.4 ± 1.7 | 52.1 ± 6.1 | 24.5 ± 2.6 | 7.7 ± 1.4 | 15.3 ± 2.0 | 6.4 ± 1.2 |
10 μM | <4.9 | 24.7 ± 2.0 | 24.4 ± 4.0 | <2.2 | 5.9 ± 0.4 | 4.1 ± 0.7 |