Summary of the prediction for CYP3A4 induction using marketed drugs
| Cutoff Criteria | Number of Drugs | Sensitivity (%) | Specificity (%) | Concordance (%) | |||
|---|---|---|---|---|---|---|---|
| True Positive | False Positive | True Negative | False Negative | ||||
| Twofold | 15 | 4 | 2 | 2 | 88.2 | 33.3 | 73.9 |
| Fourfold | 14 | 3 | 5 | 1 | 93.3 | 62.5 | 82.6 |
| 10% of rifampicin | 15 | 2 | 5 | 1 | 93.8 | 71.4 | 87.0 |
| 20% of rifampicin | 7 | 6 | 8 | 2 | 77.8 | 57.1 | 65.2 |