Fold-induction of CYP1A2, CYP2B6, CYP2C9, and CYP3A4 for test azole and reference compounds
| Compounds | Fold-induction | Ratio | |||
|---|---|---|---|---|---|
| CYP1A2 | CYP2B6 | CYP2C9 | CYP3A4 | (3A4/2B6) | |
| Azoles | |||||
| Bifonazole | 11.35 | 5.42 | 1.12 | 6.89 | 1.27 |
| Climbazole | 4.08 | 6.79 | 1.65 | 12.13 | 1.79 |
| Clotrimazole | 4.44 | 8.26 | 1.84 | 17.05 | 2.06 |
| Econazole | 8.11 | 6.44 | 1.35 | 5.45 | 0.85 |
| Fenbuconazole | 3.14 | 7.36 | 1.96 | 7.42 | 1.01 |
| Fluconazole | 0.97 | 1.57 | 1.20 | 1.59 | 1.01 |
| Hexaconazole | 3.21 | 6.25 | 1.85 | 6.76 | 1.08 |
| Imazalil | 6.31 | 9.04 | 1.66 | 9.81 | 1.09 |
| Isoconazole | 3.30 | 8.45 | 2.14 | 11.99 | 1.42 |
| Lanoconazole | 7.91 | 12.35 | 1.13 | 7.62 | 0.62 |
| Luliconazole | 9.32 | 9.20 | 1.37 | 5.23 | 0.57 |
| Miconazole | 6.41 | 7.52 | 1.74 | 13.90 | 1.85 |
| Metabolite of miconazole | 1.40 | 3.82 | 1.02 | 2.89 | 0.76 |
| Myclobutanil | 1.90 | 8.06 | 1.72 | 6.96 | 0.86 |
| Oxiconazole | 9.29 | 6.34 | 1.27 | 8.12 | 1.28 |
| Propiconazole | 3.74 | 7.00 | 2.05 | 6.83 | 0.98 |
| Tebuconazole | 3.49 | 5.29 | 1.69 | 5.99 | 1.13 |
| Tioconazole | 3.12 | 7.75 | 1.34 | 4.45 | 0.57 |
| Triflumizole | 3.38 | 5.62 | 1.20 | 5.84 | 1.04 |
| Uniconazole | 5.52 | 11.22 | 2.00 | 8.33 | 0.74 |
| Voriconazole | 1.27 | 2.72 | 1.26 | 3.60 | 1.32 |
| Metabolite of voriconazole | 1.04 | 1.42 | 0.92 | 1.06 | 0.75 |
| Reference compounds | |||||
| Rifampicin (10 μM) | 0.87 | 9.78 | 2.79 | 32.20 | 3.29 |
| Phenobarbital (750 μM) | 1.40 | 15.78 | 2.83 | 21.56 | 1.37 |
| 3-MC (1 μM) | 16.40 | 2.14 | 1.29 | 0.72 | 0.34 |
| CITCO (1 μM) | 0.92 | 7.43 | 1.07 | 3.43 | 0.46 |
| Probenecid (10 μM) | 1.10 | 1.71 | 1.28 | 1.89 | 1.11 |
Each fold-induction value represents the mean (n = 3–6; n refers to the number of wells in a single hepatocyte experiment).