TABLE 5

Administration with food moderately increases odanacatib plasma concentrations and exposures

PK parameterLow-fat meal/fastedHigh-fat meal/fasted
AUC0-∞1.15 (1.04–1.28)1.63 (1.47–1.81)
Cmax1.16 (1.07–1.25)1.91 (1.77–2.07)
Tmaxa5.0 (2.8, 84.0)10.5 (2.8, 24.1)
t1/2b87.9 (20.9)78.7 (13.2)

  • Data are reported as the GMR (90% CI), unless otherwise indicated.

  • ↵a Median values (minimum, maximum), not ratio, are reported for Tmax.

  • ↵b Harmonic mean values (jack-knife S.D.), not ratio, are reported for t1/2.