The absolute bioavailability of 10- and 50-mg oral doses of odanacatib
| Dose and food status | Na | Geometric mean (90% CI) |
|---|---|---|
| 10 mg fasted | 17 | 0.70 (0.64–0.77) |
| 50 mg fasted | 18 | 0.30 (0.27–0.34) |
| 50 mg with low-fat meal | 9 | 0.36 (0.31–0.42) |
| 50 mg with high-fat meal | 9 | 0.49 (0.43–0.57) |
All doses listed above reflect oral administration, and were administered with a reference i.v. dose of 1 mg 13C-labeled odanacatib to determine absolute bioavailability.
↵a N is less than 24 for fasted treatments and less than 12 for fed treatments because, for some subjects, AUC0-∞ could not be determined due to insufficient data in the terminal phase.