Parameter estimates by Emax model for LY2940094 plasma concentration-receptor occupancy (%) after single oral administration to human subjects
| Region of Interest | Estimate | S.E. | 95% CI | |
|---|---|---|---|---|
| Lower | Upper | |||
| Prefrontal cortex | ||||
| Emax | 100% (Fixed) | |||
| EC50 (ng/ml) | 2.94 | 0.512 | 1.81 | 4.07 |
| Residual S.D. (%) | 6.91 | 1.46 | 3.70 | 10.1 |
| Intersubject S.D. (%) | 12.5 | 2.98 | 5.96 | 19.1 |
| Occipital cortex | ||||
| Emax | 100% (fixed) | |||
| EC50 (ng/ml) | 3.46 | 0.685 | 1.96 | 4.97 |
| Residual S.D. (%) | 7.81 | 1.66 | 4.14 | 11.5 |
| Intersubject S.D. (%) | 13.9 | 3.35 | 6.48 | 21.2 |
| Putamen | ||||
| Emax | 100% (fixed) | |||
| EC50 (ng/ml) | 2.97 | 0.572 | 1.71 | 4.23 |
| Residual S.D. (%) | 5.77 | 1.25 | 3.02 | 8.52 |
| Intersubject S.D. (%) | 17.0 | 3.76 | 8.76 | 25.3 |
| Thalamus | ||||
| Emax | 100% (fixed) | |||
| EC50 (ng/ml) | 2.64 | 0.480 | 1.58 | 3.70 |
| Residual S.D. (%) | 5.42 | 1.18 | 2.82 | 8.03 |
| Intersubject S.D. (%) | 15.42 | 3.44 | 7.84 | 23.0 |
Emax, maximum % NOP receptor occupancy; CI, confidence interval; EC50, LY2940094 concentration that induces 50% receptor occupancy.