TABLE 1
Structures of fluoroquinolone compounds tested in this study
Substructures of positions C1–C5 in a quinolone scaffold are common among all compounds. Each substructure of positions C6–C8 is shown below.
| Common Scaffold |  | ||
|---|---|---|---|
| Position | |||
| C-6 | C-7 | C-8 | |
| Compound 1 | —H |  | —O— |
| Compound 2 | —H |  | —O— |
| Compound 3 | —F |  | —O— |
| Compound 4 | —F |  | —O— |
| Compound 5 | —F |  |  |
| Compound 6 | —F |  | —O— |
| Compound 7 | —F |  | —O— |
| Compound 8 | —F |  | —O— |
| Compound 9 | —F |  |  |
| Compound 10 | —F |  | —O— |