TABLE 1

Phenotype data for OATP1B1 (SLCO1B1)

PhenotypeDiplotypeRelative AbundanceCV
%
ET*1a/*1a174
*1a/*1b
*1a/*14
*1a/*35
IT*1a/*50.6854
*1a/*15
*1b/*15
*5/*14
*14/*15
PT*5/*50.3735
*15*15
*5/*15
UT*1b/*351.4746
*1b/*14
*14/*35
  • Relative abundance and the related population variability of each phenotype was obtained from in-house meta-analysis of published studies (Tirona et al., 2001; Iwai et al., 2004; Kameyama et al., 2005; Nozawa et al., 2005; Ho et al., 2006, 2007; Couvert et al., 2008; Deng et al., 2008; Choi et al., 2011; de Graan et al., 2012; Lancaster et al., 2012; Nies et al., 2013). Diplotypes associated with each phenotype definition are also summarized. All combinations of a given diplotype have been included in the model (e.g., *1a/*1b and *1b/*1a) but for simplicity are not included in this table.