TABLE 3

Weighted mean, CV, and geometric mean of total membrane protein abundance of hepatic drug transporters obtained from meta-analysis of measurements in liver tissue without exclusion criteria applied

Transporter	Mean^{^a}	CV Percent	Geometric Mean^{^a}	No. of Samples	No. of Studies	Heterogeneity
Transporter	Mean^{^a}	CV Percent	Geometric Mean^{^a}	No. of Samples	No. of Studies	P	Class
OATP1B1 (SLCO1B1)	3.18	92.1	2.34	280	7	0.0195	Moderate
OATP1B3 (SLCO1B3)	2.73	117	1.78	289	7	0.177	Low
OATP2B1 (SLCO2B1)	0.956	58.6	0.825	277	7	0.658	Low
ENT1 (SLC9A1)	0.489	24.3	0.475	17	1	N/A	N/A
NTCP (SLC10A1)	0.935	66.7	0.778	94	4	0.121	Low
MCT1 (SLC16A1)	0.58	39	0.541	17	1	N/A	N/A
OCT1 (SLC22A1)	1.38	50.7	1.23	67	2	0.287	Low
OAT2 (SLC22A7)	0.471	75.5	0.376	25	2	0.00268	Moderate
OAT7 (SLC22A9)	0.41	50.9	0.365	12	1	N/A	N/A
MATE1 (SLC47A1)	0.196	63	0.166	83	3	0.000302	High
OCT3 (SLC22A3)	0.055	60.6	0.047	11	1	N/A	N/A
CNT1 (SLC28A1)	0.299	33	0.284	17	1	N/A	N/A
ABCA6	2.58	41.8	2.38	17	1	N/A	N/A
ABCA8	0.486	33.3	0.461	16	1	N/A	N/A
P-gp/MDR1 (ABCB1)	0.2	64.2	0.168	290	6	0.216	Low
MDR3 (ABCB4)	0.668	0.422	63.1	17	1	N/A	N/A
BSEP (ABCB11)	0.815	45.6	0.741	99	4	0.326	Low
MRP1 (ABCC1)	0.568	111	0.38	27	2	0.0492	Moderate
MRP2 (ABCC2)	0.452	50.6	0.403	162	6	0.419	Low
MRP3 (ABCC3)	0.171	31.8	0.163	67	2	0.76	Low
MRP4 (ABCC4)	0.0546	148	0.0305	8	2	0.0677	Low
MRP5 (ABCC5)	0.719	8.63	0.716	3	1	N/A	N/A
MRP6 (ABCC6)	0.679	46.6	0.615	29	2	0.466	Low
BCRP (ABCG2)	0.0582	76.1	0.0463	146	5	0.00103	Moderate

References for each transporter are provided in the Supplemental Material. BSEP, bile salt efflux pump; MATE, multidrug and toxin extrusion protein; MDR, multidrug resistance gene; N/A, XXX Not applicable (only 1 study); NTCP, sodium taurocholate cotransporting polypeptide; OCT, organic cation transporter.
↵^a Values are given as picomoles per 10⁶ hepatocytes.