Pharmacokinetic variables of rifampicin, trimethoprim, and clopidogrel and its metabolites (2-oxo clopidogrel, clopidogrel carboxylic acid, and clopidogrel acyl-β-glucuronide)
Data are presented as mean ± S.D.
| Variables | Rifampicin 600 mg | Trimethoprim 200 mg | Clopidogrel 300 mg | |||
|---|---|---|---|---|---|---|
| Clopidogrel | 2-Oxo clopidogrel | Clopidogrel carboxylic acid | Clopidogrel acyl-β-glucuronide | |||
| Cmax (μg/ml) | 24.3 ± 5.5 | 3.20 ± 0.96 | 0.0033 ± 0.0022 | 0.0055 ± 0.0028 | 10.4 ± 2.6 | 5.83 ± 3.66 |
| tmax (h) | 1.31 ± 0.88 | 1.69 ± 1.25 | 0.88 ± 0.58 | 0.75 ± 0.27 | 1.31 ± 0.75 | 2.06 ± 0.62 |
| t1/2 (h) | 3.34 ± 0.63 | 8.58 ± 1.83 | 4.85 ± 3.89 | 7.20 ± 3.38 | 8.28 ± 1.41 | 5.25 ± 1.06 |
| AUC0–t (μg⋅h/ml) | 140 ± 33 | 28.2 ± 5.1 | 0.0061 ± 0.0037 | 0.012 ± 0.004 | 41.0 ± 7.0 | 29.1 ± 14.9 |
| AUC0–∞ (μg⋅h/ml) | 142 ± 34 | 33.4 ± 7.1 | 0.0068 ± 0.0045 | 0.013 ± 0.003 | 44.3 ± 8.0 | 30.0 ± 15.3 |
Cmax, peak plasma concentration; tmax, time to Cmax; t1/2, elimination half-life; AUC0–t, area under the plasma concentration-time curve from 0 to t (24 hours for rifampicin, trimethoprim, clopidogrel carboxylic acid and clopidogrel acyl-β-glucuronide, 8 hours for clopidogrel, and 12 hours for 2-oxo clopidogrel); AUC0–∞, area under the plasma concentration-time curve from 0 to infinity.