TABLE 1 

Enantioselectivity of Kpuu in human hepatocytes

Kpuu was measured at hepatocyte cell density of 0.5 million cells/ml, 1 μM test compound concentration, and 4-hour incubation time.

R-EnantiomerKpuu (R)S-EnantiomerKpuu (S)
PF-06649298
Embedded Image4.8PF-06649297
Embedded Image0.4
PF-06794266
Embedded Image15PF-06793742
Embedded Image0.6
PF-06761281 
Embedded Image61NANA
PF-06746350
Embedded Image10NANA
PF-06741415aEmbedded Image48NANA
  • NA = not available.aS enantiomer due to hydroxyl group replaced with hydrogen.