TABLE 2

Expression of mRNA for SLC drug transporters in the human iris-ciliary body, ciliary body, or iris

Minus signs indicate not detected, plus signs indicate detected, and plus/minus signs indicate that mRNA expression was low to negligible. Blank areas indicate that the study did not examine expression of the respective SLC drug transporter.

TransporterIris-Ciliary BodyCiliary BodyIris
Zhang et al. (2008)Dahlin et al. (2013)Lee et al. (2015)Dahlin et al. (2013)Lee et al. (2015)
OATPs
 OATP1A2++/−++/−
 OATP1B1++
 OATP1B3++/−
 OATP2B1+++++
 OATP1C1+/−+/−
 OATP2A1++/−
 OATP3A1++
 OATP4A1++
 OATP4C1
 OATP5A1+/−+/−
 OATP6A1
OATs
 OAT1+++++
 OAT2++
 OAT3+++++
 OAT4+/−+
Bile acid transporters
 ASBT++
 NTCP++
Dicarboxylate transporters
 NaDC1+/−
 NaDC3++
Organic cation transporters
 OCT1+++
 OCT2+++
 OCT3+++
 OCTN1+
 OCTN2+++
 MATE1++
 MATE2++
Peptide transporters
 PEPT1+/−++
 PEPT2+
  • The studies by Zhang et al. (2008), Dahlin et al. (2013), and Lee et al. (2015) used qPCR, microarray, and microarray for mRNA detection, respectively. The numbers of individual donor eyes used in these studies are as follows: Dahlin et al. (n = 15), Lee et al. (n = 5 to 6), and Zhang et al. (n = 3). ASBT, apical sodium-dependent bile salt transporter; NTCP, sodium taurocholate cotransporter; qPCR, quantitative polymerase chain reaction; RT-PCR, reverse-transcription polymerase chain reaction.