TABLE 1

Expression of mRNA for ABC drug transporters in the human iris-ciliary body, ciliary body, or iris

Minus signs indicate not detected, plus signs indicate detected, and plus/minus signs indicate that mRNA expression was low to negligible. Blank areas indicate that the study did not examine expression of the respective ABC drug transporter.

TransporterIris-Ciliary BodyCiliary BodyIris
Chen et al. (2013)Zhang et al. (2008)Dahlin et al. (2013)Lee et al. (2015)Dahlin et al. (2013)Lee et al. (2015)
MRP1++++
MRP2++++
MRP3+++++
MRP4+++++
MRP5+++++
MRP6++/−++
MRP7+++
BCRP++++/−+/−
P-gp++++++
  • The studies by Chen et al. (2013), Dahlin et al. (2013), Lee et al. (2015), Pelis et al. (2009), and Zhang et al. (2008) used qPCR, microarray, microarray, RT-PCR, and qPCR for mRNA detection, respectively. The numbers of individual donor eyes used in these studies are as follows: Chen et al. (n = 6), Dahlin et al. (n = 15), Lee et al. (n = 5 to 6), Pelis et al. (n = 1), and Zhang et al. (n = 3). qPCR, quantitative polymerase chain reaction; RT-PCR, reverse-transcription polymerase chain reaction.