TABLE 1

Summary of the in vivo bupropion DDI clinical studies used for predictions

PrecipitantPrecipitant Dose (Duration)Precipitant Dose IntervalBupropion Victim Drug DoseBupropion Dose IntervalObserved DDI (AUCR)Reference
mgmg
Carbamazepine942 (wk)QD150SD0.10Ketter et al. (1995)
Cimetidine800 (1 d)QD300SD1.05Kustra et al. (1999)
Efavirenz600 (15 d)QD150SD0.45Robertson et al. (2008)
Nelfinavir1250 (14 d)BID150SD0.92Kirby et al. (2011)
Rifampin600 (7 d)QD150SD0.33Chung et al. (2011)
600 (10 d)QD150SD0.33Loboz et al. (2006)
600 (10 d)QD150SD0.52Kharasch et al. (2008a)
Ritonavir100 (23 d)BID150SD0.78Park et al. (2010)
200–400 (14 d)TID150SD0.67Kirby et al. (2011)
600 (23 d)BID150SD0.34Park et al. (2010)
200–300 (18 d)BID150SD0.98Kharasch et al. (2008b)
200–300 (3 d)BID150SD0.84Kharasch et al. (2008b)
200 (2 d)BID75SD1.2Hesse et al. (2006)
Teriflunomide14–70 (14 d)QD150SD0.91Sheedy et al. (1977)
  • BID, twice daily; QD, every day; SD, single dose; TID, three times daily.