TABLE 2

Reversible CYP2D6 inhibition kinetic parameters at pH 7.0 and pH 7.4.

Ratio between pH 7.0 and pH 7.4 results are given.

Substrate/Inhibitor	fu_{mic pH 7}	K_{i,u pH 7}	fu_{mic pH 7.4}	K_{i,u pH 7.4}	K_i,u
		μM		μM	Ratio
Bufuralol
Quinidine	0.934	0.090	0.939	0.041	2.21
Amiodarone	0.0020	0.096	0.0016	0.112	0.86
Desethylamiodarone	0.0046	0.078	0.0043	0.087	0.89
Clozapine	0.843	28.6	0.830	28.4	1.01
Paroxetine	0.493^{^a}	0.46	0.410^{^a}	0.33	1.39
Dextromethorphan
Quinidine	0.946^{^a}	0.051	0.951^{^a}	0.026	1.95
Amiodarone	0.0026^{^a}	0.083	0.0020^{^a}	0.134	0.62
Desethylamiodarone	0.0057^{^a}	0.043	0.0054^{^a}	0.034	1.27
Clozapine	0.870^{^a}	14.9	0.859^{^a}	15.6	0.96
Paroxetine	0.549^{^a}	0.32	0.465^{^a}	0.28	1.14

↵^a fu_mic for inhibitor under in vitro assay conditions calculated from Austin et al. (2002).