Summary of mean (± S.D.) MPR calculated from AUC0-8 (N = 4)
| Tg-Composite) | WT | hPXR-CAR | ||||
|---|---|---|---|---|---|---|
| Vehicle | Rifampin | Vehicle | Rifampin | Vehicle | Rifampin | |
| NDM/tamoxifen | 1.0 ± 0.3 | 0.92 ± 0.61 | 0.23 ± 0.14 | 0.16 ± 0.23 | 0.29 ± 0.09 | 0.38 ± 0.13 |
| 4OHT/tamoxifen | 4.1 ± 1.0 | 5.4 ± 3.8 | 0.27 ± 0.12 | 0.19 ± 0.14 | 0.79 ± 0.32 | 1.0 ± 0.16 |
| Endoxifen/tamoxifen | 1.1 ± 0.2 | 3.8 ± 2.3* | 0.46 ± 0.16 | 0.18 ± 0.12 | 0.52 ± 0.18 | 0.68 ± 0.32 |
↵* P < 0.05 relative to vehicle.