TABLE 3

Comparison of testosterone and androstenedione metabolism by CYP2B6 to the previously published results for CYP2B1 and CYP2B4

P450aTestosteroneAndrostenedione
16β/16αTotalb16β/16αTotalb
%%
CYP2B1
 WT1.01008.0100
 F206A mutant0.2730.822
 V367A mutant1.6122462
CYP2B4
 WT0.11006.0100
 F206A mutantNDNDNDND
 V367A mutant1.79810.3340
CYP2B6
 WT5.310016.6100
 F206A mutant0.1150.134
 V367A mutant1.210812.6320

  • ND, not determined.

  • ↵a The data for CYP2B6 were calculated from Figs. 2 and 3. The data for CYP2B1 (He et al., 1994, 1995) and CYP2B4 (Szklarz et al., 1996; Hernandez et al., 2006) were previously published.

  • ↵b The catalytic activity of the WT was designated as 100% for each of the P450s.