Drug | Cmax | IC20 (24 h) | Maximum In Vitro Concentration Tested |
---|---|---|---|
µM | |||
Group 1: drugs involved in clinical cholestasis | |||
BOS | 7.4 | 120 | 100 |
CPZ | 0.2 | 50 | 50 |
CsA | 1.15 | >300 | 50 |
NEF | 4.26 | 50 | 75 |
TRO | 6.39 | 65 | 50 |
Group 2: drugs involved in rare cases of clinical cholestasis | |||
CIM | 4.9 | 4000 | 4000 |
DIC | 8 | 375 | 200 |
ENT | 3.9 | 250 | 100 |
MET | 7.74 | 3000 | 3000 |
PER | 2 | 25 | 20 |
TAC | 0.09 | 60 | 50 |
TOL | 23 | 70 | 100 |
Group 3: drugs not involved in clinical cholestasis | |||
AMI | 0.8 | 20 | 20 |
APAP | 139 | 20,000 | 25,000 |
BUS | 0.01 | >300 | 100 |
FIA | 0.64 | >300 | 100 |
PIO | 4.2 | 200 | 100 |
XIM | 0.3 | >300 | 100 |