| pmol/min per pmol P450 | μM | μM | μl/min per pmol P450 | % |
CYP2D6*1 | 1.17 ± 0.04 | 1.80 ± 0.21 | | 0.66 ± 0.06 | 100.00 |
CYP2D6*2 (R297C; S486T) | 0.77 ± 0.02* | 1.77 ± 0.45 | 2.51 e3 ± 1.06 e3 | 0.45 ± 0.10* | 67.83 |
CYP2D6*10 (P34S; S486T) | 0.09 ± 0.01* | 3.62 ± 1.70 | | 0.03 ± 0.01* | 4.07 |
CYP2D6*87 (A5V) | 0.56 ± 0.04* | 5.33 ± 1.45* | | 0.11 ± 0.02* | 16.83 |
CYP2D6*88 (V104A) | 1.38 ± 0.04* | 2.18 ± 0.16 | 531.30 ± 80.47 | 0.63 ± 0.03 | 95.79 |
CYP2D6*89 (L142S) | 1.36 ± 0.09* | 1.86 ± 0.32 | 88.35 ± 34.55 | 0.74 ± 0.08 | 111.85 |
CYP2D6*90 (K147R) | 0.52 ± 0.04* | 3.32 ± 1.31 | 278.37 ± 81.94 | 0.17 ± 0.05* | 25.05 |
CYP2D6*91 (C161S) | 0.99 ± 0.18* | 7.97 ± 3.44* | | 0.13 ± 0.03* | 20.58 |
CYP2D6*92 (218 frameshift) | ND | ND | | ND | ND |
CYP2D6*93 (T249P) | 0.46 ± 0.04* | 5.75 ± 0.64* | 192.83 ± 116.20 | 0.08 ± 0.00* | 12.20 |
CYP2D6*94 (D337G) | 0.97 ± 0.00* | 2.59 ± 0.68 | | 0.39 ± 0.10* | 58.23 |
CYP2D6*95 (R388H) | 0.48 ± 0.00* | 2.87 ± 0.55 | | 0.17 ± 0.03* | 25.65 |
CYP2D6*96 (424STOP) | ND | ND | | ND | ND |
CYP2D6*97 (F457L) | 0.77 ± 0.03* | 1.83 ± 0.17 | | 0.42 ± 0.02* | 64.57 |
CYP2D6*98 (H463D) | 0.66 ± 0.01* | 1.49 ± 0.26 | | 0.45 ± 0.07* | 67.97 |
R25Q | 0.36 ± 0.01* | 1.04 ± 0.23 | | 0.35 ± 0.08* | 52.53 |
F164L | 0.66 ± 0.03* | 1.99 ± 0.47 | 3.05e3 ± 4.14 e3 | 0.34 ± 0.06* | 51.17 |
E215K | 9.48 e3 ± 2.43 e3* | 2.31 e5 ± 5.10 e4* | | 0.04 ± 0.00* | 6.15 |
F219S | 1.02 ± 0.03* | 2.18 ± 0.03 | 656.43 ± 314.34 | 0.47 ± 0.01* | 71.00 |
V327M | 0.59 ± 0.01* | 2.06 ± 0.26 | | 0.29 ± 0.03* | 43.77 |
D336N | 0.87 ± 0.01* | 1.61 ± 0.13 | | 0.54 ± 0.03 | 81.61 |
V342M | 1.06 ± 0.02 | 1.93 ± 0.17 | | 0.55 ± 0.04 | 83.16 |
R344Q | 0.76 ± 0.03* | 1.42 ± 0.20 | | 0.54 ± 0.05 | 83.28 |
R440C | 1.85 ± 0.10* | 1.28 ± 0.12 | 79.04 ± 24.95 | 1.44 ± 0.05* | 219.08 |
R497C | 0.46 ± 0.01* | 1.20 ± 0.09 | | 0.39 ± 0.02* | 58.71 |