TABLE 1

Study designs, experimental conditions, and measured endpoints for the in vivo studies

Study	Dose	Formulation	Mouse Strain	Collected Samples	Measured Endpoints
	mg/kg
Pharmacokinetics	25	MCT	CD1, female	Plasma, brain	GDC-0084 concentrations
		MCT	CD1, female	Plasma, brain	PD modulation (pAkt, pS6)
MALDI imaging	15	MCT	CD-1 Nude, female intracranial tumor-bearing	Brain	GDC-0084 brain distribution
Efficacy	15	MCT	CD-1 Nude, female intracranial tumor-bearing	Plasma, brain, tumors	Tumor volumes
	15	MCT	CD-1 Nude, female intracranial tumor-bearing	Plasma, brain, tumors	GS2 tumors: GDC-0084 plasma, brain and tumor concentrations, PD modulation