PK parameters of endoxifen in hCYP2D6 mice
Parameters (means ± S.D.) are shown for vehicle (n = 6) and paroxetine (n = 6) pretreated groups.
| Group | t1/2 | Cmax | AUCall |
|---|---|---|---|
| h | ng/ml | h⋅ng/ml | |
| Vehicle | 14.3 ± 4.7 | 132 ± 46 | 3508 ± 797 |
| Paroxetine | 13.8 ± 3.1 | 104 ± 12 | 2525 ± 321* |
| P value | 0.416 | 0.094 | 0.009 |
t1/2, half-life. *P <0.05.