TABLE 1

Spearman’s rank correlation of conversion of NDT to endoxifen with P450 probe substrate metabolism in a panel of 13 HLMs

Spearman’s rank correlation coefficient of NDT hydroxylation with metabolism of P450 probe substrates is shown. Probe substrate values were provided by the vendor.

Enzyme	Probe Substrate Activity	SRCC with NDT Hydroxylation	P Value
1A2	Phenacetin O-deethylation	−0.289	0.360
2A6	Coumarin 7-hydroxylation	0.161	0.600
2B6	S-mephenytoin N-demethylation	0.572	0.045
2C8	Paclitaxel 6α-hydroxylation	0.380	0.186
2C9	Diclofenac 4′-hydroxylation	0.526	0.076
2C19	S-mephenytoin 4′-hydroxylation	−0.220	0.444
2D6	Bufuralol 1′-hydroxylation	0.698	0.010
2E1	Chlorzoxazone 6-hydroxylation	0.311	0.281
3A4	Testosterone 6β-hydroxylation	−0.005	0.993
4A11	Lauric acid 12-hydroxylation	−0.290	0.316

SRCC, Spearman’s rank correlation coefficient.