TABLE 1

Rosuvastatin and ronacaleret pharmacokinetic parameters [geometric mean (CVb%)]

Treatment	N	AUC(0-∞)	C_max	T_max^a	t_1/2
		ng.h/ml	ng/ml	h	h
Rosuvastatin alone	23	59.1 (50.1)	4.39 (54.1)	4.00 (2.00–6.00)	11.3 (22.1)
Rosuvastatin + ronacaleret (single dose)	20	31.3 (68.0)	2.91 (52.8)	4.00 (0.50–4.00)	11.0 (65.6)
Rosuvastatin + ronacaleret (multidose)	23	29.9 (71.6)^{^b}	2.96 (77.0)	4.00 (1.00–6.00)	10.9 (35.8)^{^b}
Ronacaleret (multidose)	24	13700 (78.7)	2320 (80.5)	1.5 (1.00–4.00)	5.08 (18.7)

AUC(0-∞), area under the plasma concentration-time curve from time zero to infinity; CVb, between-subject variability.
↵^a Median (range).
↵^b n = 22.