Inhibition of thiamine uptake by JAKi and other xenobiotics
Values represent the mean ± S.D. of triplicate determinations in a representative experiment of three independent experiments.
| IC50 Value for Thiamine Uptake | |||
|---|---|---|---|
| Compound | Caco-2 | THTR-1 | THTR-2 |
| µM | µM | µM | |
| Fedratinib | 0.940 ± 0.080 | 7.10 ± 1.26 | 1.36 ± 0.59 |
| AZD1480 | 183 ± 68.9 | 22.2 ± 6.20 | 15.3 ± 2.90 |
| Cerdulatinib | >300 | 276 ± 117 | >300 |
| Momelotinib | >30.0 | >30.0 | >30.0 |
| Trimethoprim | 154 ± 22.4 | 6.84 ± 1.68 | 5.56 ± 0.65 |
| Oxythiamine | 198 ± 16.0 | 67.3 ± 7.50 | 66.4 ± 21.4 |
| Amprolium | 9.40 ± 2.80 | 2.60 ± 0.93 | 0.620 ± 0.270 |