TABLE 5

Statistical analysis of AUC and Cmax for LY2140023, LY404039, valacyclovir, and acyclovir

Geometric mean (CV%) are presented for each parameter except for tmax, which presents Median (Min − Max).

CompoundParameterLY2140023 Alone (Reference)LY2140023 + Valacyclovir (Test)Ratio90% CI
nLS Geometric Mean90% CInLS Geometric Mean90% CI
LY2140023AUC(0-∞) (ng⋅h/ml)201353.0(1216.3, 1505.1)201221.9(1098.4, 1359.3)0.90(0.87, 0.94)
Cmax (ng/ml)20310.4(279.9, 344.2)20275.0(247.9, 304.9)0.89(0.83, 0.95)
LY404039AUC(0-∞) (ng⋅h/mL)202667.1(2461.9, 2889.4)202502.4(2309.9, 2711.0)0.94(0.91, 0.97)
Cmax (ng/mL)20484.3(447.8, 523.8)20447.1(413.4, 483.6)0.92(0.87, 0.98)
Valacyclovir Alone (Reference)Valacyclovir + LY2140023 (Test)
ValacyclovirAUC(0-3) (ng⋅h/ml)22309.1(251.1, 380.6)20277.5(223.5, 344.6)0.90(0.71, 1.13)
Cmax (ng/ml)23245.4(217.0,277.5)20258.3(226.2, 294.8)1.05(0.89, 1.24)
AcyclovirAUC(0-∞) (ng⋅h/ml)2317501.8(16255.0, 18844.2)2017102.5(15877.0, 18422.5)0.98(0.95, 1.00)
Cmax (ng/ml)234397.9(4025.2, 4805.0)204604.4(4190.1, 5059.6)1.05(0.94, 1.16)
  • Ratio is Test/Reference.