Pharmacokinetic parameters for valacyclovir and acyclovir after a single 1000-mg dose of valacyclovir administered alone or with LY2140023
Geometric mean (CV%) are presented for each parameter except for tmax, which presents Median (Min − Max).
| Treatment | Valacyclovir Parameters | Acyclovir Parameters | ||
|---|---|---|---|---|
| Valacyclovir 1000 mg | LY2140023 80 mg + Valacyclovir 1000 mg | Valacyclovir 1000 mg | LY2140023 80 mg + Valacyclovir 1000 mg | |
| N | 23 | 20 | 23 | 20 |
| Cmax (ng/ml) | 245 (41) | 255 (29) | 4400 (23) | 4550 (28) |
| tmaxa (hour) | 2.00 (0.75–5.00) | 2.00 (0.75–5.00) | 2.50 (1.00–5.00) | 2.51 (1.25–5.00) |
| t1/2 (hour) | 3.70 (16) | 3.63 (17) | ||
| AUC(0-3) (ng⋅h/ml) | 311 (60)b | 270 (67) | ||
| AUC(0-∞) (ng⋅h/ml) | 17,500 (20) | 17,000 (23) | ||
| fe | 0.00703 (64.7) | 0.00776 (25.4) | 0.460 (32.0) | 0.488 (12.3) |
| CLr (l/h) | 15.7 (79.5) | 18.6 (23.4) | 18.4 (42.0) | 20.0 (24.7) |