TABLE 2

Intrinsic clearance and protein binding values of losartan, meloxicam, and sildenafil measured in rP450 and HLM systems

Testing System	Losartan		Meloxicam		Sildenafil
Testing System	CL_int,u	f_u	CL_int,u	f_u	CL_int,u	f_u
	min⁻¹		min⁻¹		min⁻¹
rCYP1A2	0.0007	0.80	0.0029	0.81	0	0.49
rCYP2C9	0.0068	0.90	0.0039	0.91	0.0417	0.58
rCYP2C19	0.0006	0.91	0.0073	0.95	0	0.61
rCYP2D6	0	0.83	0.0010	0.91	0.0128	0.49
rCYP3A4	0.0134	0.82	0.0133	0.84	1.2000	0.51
HLMs	0.0042	0.88	0.0004	0.97	0.2663	0.34