RIS values calculated using induction response measured by CYP3A4 mRNA level and enzyme activity in HepatoCells
| Compound | RIS Based on mRNA | RIS Based on Enzyme Activity | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Lot 2B | Lot 3A | Lot 3B | Mean | %CV | Lot 2B | Lot 3A | Lot 3B | Mean | %CV | |
| Rifampicin | 19.1 | 24.8 | 21.5 | 21.8 | 13% | 23.8 | 23.0 | 18.3 | 21.7 | 14% |
| Phenytoin | 7.5 | 12.1 | 8.5 | 9.4 | 26% | 1.8 | 2.3 | 2.4 | 2.2 | 13% |
| Carbamazepine | 0.76 | 0.77 | 1.3 | 0.9 | 31% | 0.67 | 0.8 | 0.9 | 0.8 | 17% |
| Phenobarbital | 5.2 | 5.0 | 2.5 | 4.3 | 35% | 2.9 | 4.2 | 4.0 | 3.7 | 18% |
| Terbinafine | 0.13 | 0.26 | 0.19 | 0.19 | 34% | 0.15 | 0.23 | 0.17 | 0.2 | 21% |
| Pioglitazone | 0.28 | 0.37 | 0.21 | 0.29 | 28% | 0.12 | 0.20 | 0.28 | 0.2 | 42% |
| Sulfinpyrazone | 1.2 | 1.8 | 1.1 | 1.4 | 25% | 1.5 | 1.4 | 1.2 | 1.3 | 10% |
| Probenecid | 2.8 | 3.2 | 2.4 | 2.8 | 13% | 1.5 | 1.0 | 0.8 | 1.1 | 33% |
| Dexamethasone | 0.0013 | 0.0024 | 0.0012 | 0.0016 | 43% | 0.00054 | 0.00041 | 0.00043 | 0.0005 | 15% |
| Nifedipine | 0.10 | 0.12 | 0.16 | 0.13 | 22% | 0.09 | 0.09 | 0.04 | 0.0697 | 39% |
| Rosiglitazone | 0.043 | 0.065 | 0.070 | 0.059 | 25% | 0.019 | 0.028 | 0.024 | 0.0237 | 18% |
| Omeprazole | 0.069 | 0.073 | 0.079 | 0.074 | 7% | 0.015 | 0.009 | 0.007 | 0.0103 | 39% |
| Clotrimazole | 0.0028 | 0.0051 | 0.0052 | 0.0044 | 7% | NA | NA | NA | ||
| Mean %CV | 24% | 23% | ||||||||