Compounds | Observed % AUC Change | Predicted % AUC Change Based on mRNA | Predicted % AUC Change Based on Activity | ||||
---|---|---|---|---|---|---|---|
Lot 2B | Lot 3A | Lot 3B | Lot 2B | Lot 3A | Lot 3B | ||
Rifampicin* | 97 | 98 | 98 | 95 | 96 | 96 | 99 |
Phenytoin* | 94 | 98 | 98 | 95 | 96 | 96 | 97 |
Carbamazepine* | 94 | 86 | 87 | 95 | 92 | 92 | 87 |
Phenobarbital | 61 | 98 | 98 | 95 | 96 | 96 | 98 |
Pioglitazone* | 26 | 36 | 35 | 29 | 17 | 23 | 34 |
Terbinafine* | 25 | 8.1 | 13 | 19 | 29 | 29 | 15 |
Sulfinpyrazone | 22 | 94 | 97 | 95 | 96 | 95 | 92 |
Probenecid | 20 | 98 | 98 | 95 | 96 | 94 | 83 |
Dexamethasone | 19 | 0.00 | 0.00 | 0.00 | 0.0 | 0.0 | 0.0 |
Nifedipine* | 4 | 4.4 | 0.89 | 8.3 | 8.9 | 2.1 | 0.63 |
Omeprazole | −25 | 1.7 | 0.14 | 0.35 | 0.11 | 0.002 | 0.017 |
Rosiglitazone | 12 | 0.53 | 0.10 | 0.20 | 0.21 | 0.077 | 0.22 |
Clotrimazole | 9.7 | 0.00 | 0.00 | 0.00 | 0 | 0 | 0 |
* Denotes that compounds were used to generate RIS calibration curves.