TABLE 3

Potential for clinical DDI based on estimated concentrations in the GI tract

CompoundsDoseAEstimated Intestinal ConcentrationBMean IC50 from Two in Vitro ExperimentsI2/IC50
mgmMmMmM
Captopril25 to 1500.46 to 2.7618.020.03 to 0.15
Cefadroxil1000 to 200010.49 to 20.984.992.10 to 4.20
Cephalexin250 to 5002.48 to 4.9813.610.18 to 0.37
Enalapril10 to 400.08 to 0.3210.660.008 to 0.03
Valacyclovir500 to 10005.54 to 11.090.4612.04 to 24.11
LY2140023800.8730.01848.5
  • A Dose obtained from Physicians' Desk Reference (1997) for oral administration.

  • B Dose divided by 250 ml (glass of water) to estimate intestinal concentration of each compound.