TABLE 1

Species differences of metabolite levels in plasma after oral administration

Australian public assessment report for vildagliptin, Department of Health and Ageing, Therapeutic Goods Administration, 2010 April. Available from: http://www.tga.gov.au/auspar/auspar-vildagliptin (accessed June 7, 2016).

SpeciesMetabolite (% of Total AUC)
Parental VildagliptinM15.3M20.2M20.7
Human268.19.556
Mouse46Trace3.817
Rat4001142
Dog23261.433
Rabbit22530.97.4
Monkey200.8724.9