Observed and simulated pharmacokinetic parameters for LB for an intravenous bolus administration of 1 mg/kg LB alone and 1 mg/kg LB with 5 mg/kg ATV to rats
Simulated data are expressed as means ± S.D. of three virtual rats from in vitro experiments in triplicate runs.
| Parameter | Observed | Simulated | ||
|---|---|---|---|---|
| LB | LB Plus ATV | LB | LB Plus ATVa | |
| AUCinf,plasma (µg · min/ml) | 435 | 509 | 493 ± 0.08 | 492 ± 29 |
| AUCinf,liver (µg ∣ min/ml) | 1020 | 789 | 1070 ± 46 | 842 ± 68 |
| Kp,liver | 2.34 | 1.55 | 2.18 ± 0.09 | 1.71 ± 0.13 |
↵a Values were determined using Ki,OATP values. Kp,liver values were 1.83 ± 0.22 using Ki,hepa values.