TABLE 8

In vitro and in vivo plasma unbound fractions (fu) (%) of IB in control and AA rats

Results are expressed as the mean ± S.D. (n = 3).

ControlAA
R-IBS-IBR-IBS-IB
In vitro0.72 ± 0.241.38 ± 0.342.51 ± 0.56b,c3.40 ± 0.57b,c
In vivoPost dosing (min)
102.21 ± 0.322.96 ± 0.605.64 ± 0.66b,c8.38 ± 3.18b,c
302.16 ± 0.293.59 ± 0.535.81 ± 0.77b,c7.42 ± 1.17b,c
Averagea2.193.275.737.90

  • In vitro, Rac-IB (at a total concentration of 50 μg/ml); in vivo, dose, rac-IB 20 mg/kg. a) Average values between 10 and 30.

  • ↵b P < 0.05 compared with controls.

  • ↵c P < 0.05 compared with its antipode.